Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.60 |
| ▸ | KIF11 | P52732 | 6/20 | 0.53 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30227292 | 0.90 | KDM4E (0.74) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL21855490 | 0.90 | KDM4E (0.74) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL22616930 | 0.85 | MAOA (0.86) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL28022464 | 0.83 | KIF11 (0.48) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL147307 | 0.82 | ROCK2 (0.73) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL150770 | 0.81 | MAOA (0.62) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL22616916 | 0.81 | MAOA (0.62) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL1181450 | 0.80 | ROCK2 (0.48) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL148317 | 0.80 | P2RY12 (0.63) | MAOAKDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL147687 | 0.79 | MAOA (0.59) | MAOAKDM4EKMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105189488-B | Carbazole compound as bromodomain inhibitor | 百时美施贵宝公司 | 2018-07-24 | — | — | CN | disclosed |
| CN-107011342-A | The preparation based on carboline and carbazole for detecting neurological dysfunction | 伊莱利利公司 | 2017-08-04 | — | — | CN | disclosed |
| CN-102325752-B | Carbazole and carboline kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2015-02-04 | — | — | CN | disclosed |
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160303-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | MAOA 3150/4885KDM4E 733/4885KMT2A 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.