Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone Aceponate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 2/20 | 0.71 |
| ▸ | PGR | P06401 | 4/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 2/20 | 1.00 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278627 | 0.95 | PGR (0.91) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL4285504 | 0.94 | PGR (0.88) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL4285507 | 0.94 | PGR (0.88) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL10380853 | 0.93 | PGR (0.87) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL10380855 | 0.93 | PGR (0.87) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL1247962 | 0.93 | PGR (0.87) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL4290159 | 0.92 | PGR (0.85) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL122187 | 0.92 | PGR (0.85) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL11438892 | 0.92 | PGR (0.85) | PGRARCHRM1NR3C2HIF1A | |
| SCHEMBL1030720 | 0.91 | PGR (0.84) | PGRARCHRM1NR3C2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2914 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250255781-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-08-14 | — | — | US | claimed |
| US-12296043-B2 | Liquisoft capsules | PATHEON SOFTGELS INC. (US) | 2025-05-13 | — | — | US | claimed |
| EP-4510999-A1 | PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS | Bristol-Myers Squibb Company (US) | 2025-02-26 | — | — | EP | claimed |
| EP-4475851-A1 | FORMULATIONS FOR TRANSDERMAL ADMINISTRATION OF ACTIVE AGENTS | Dyve Biosciences, Inc. (US) | 2024-12-18 | — | — | EP | claimed |
| EP-2677961-B1 | HYBRID CATHETER FOR VASCULAR INTERVENTION | EXIMO MEDICAL LTD (IL) | 2024-12-11 | — | — | EP | claimed |
| US-20240390265-A1 | FORMULATIONS FOR TRANSDERMAL ADMINISTRATION OF ACTIVE AGENTS | DYVE BIOSCIENCES, INC. | 2024-11-28 | — | — | US | claimed |
| EP-4433091-A1 | PROCESS AND THERAPEUTIC COMPOSITION FOR TREATING AND PREVENTING SEVERE INJECTION SITE REACTIONS | Brii Biosciences, Inc. (US) | 2024-09-25 | — | — | EP | claimed |
| EP-3603645-B1 | NOVEL USE OF GLUCOCORTICOIDS FOR THE TREATMENT OF EPITHELIAL MICROBIAL INFECTIONS OF A FLUID CONTAINING ORGAN WITH A NATURAL EXTERIOR ORIFICE IN MAMMALS | VIRBAC (FR) | 2024-08-07 | — | — | EP | claimed |
| WO-2024133513-A1 | COMPOSITION AND PRODUCTS COMPRISING AN ANTIBIOTIC AND A GLUCOCORTICOID FOR TREATING MASTITIS | VIRBAC (FR) | 2024-06-27 | — | — | WO | claimed |
| US-20240165020-A1 | LIQUISOFT CAPSULES | PATHEON SOFTGELS INC (US) | 2024-05-23 | — | — | US | claimed |
| WO-2004112800-A1 | ENHANCEMENT OF ACTIVITY AND/OR DURATION OF ACTION OF SELECTED ANTI-INFLAMMATORY STEROIDS | BODOR NICHOLAS S (US) | 2004-12-29 | — | — | WO | claimed |
| WO-2004020029-A1 | THERAPEUTIC AEROSOL DEVICE | Pari GmbH Spezialisten für effektive Inhalation (DE) | 2004-03-11 | — | — | WO | claimed |
| EP-0737062-B1 | WATER-IN-OIL LOTION CONTAINING A CORTICOSTEROID | GALDERMA SA (CH) | 1998-05-06 | — | — | EP | claimed |
| EP-0755675-B1 | Dermatological and/or pharmaceutical composition, process of preparation and utilization | OREAL (FR) | 1997-09-17 | — | — | EP | claimed |
| US-5653989-A | LOTION COMPRISING HYDROCORTISONE-21-ACETATE-17-PROPIONATE AND SELECTED WATER IN OIL EMULSION; FOR USE ON DRY SKIN | GALDERMA S.A. (CH) | 1997-08-05 | — | — | US | claimed |
| WO-1995017882-A1 | CORTICOSTEROID-CONTAINING W/O EMULSION LOTION | BEIERSDORF AG (DE) | 1995-07-06 | — | — | WO | claimed |
| EP-0217141-B1 | W/O CREAMS CONTAINING 17-PROPIONATE-21-ACETATE | Beiersdorf Aktiengesellschaft (DE) | 1990-09-26 | — | — | EP | claimed |
| EP-0217146-B1 | W/O CREAMS CONTAINING HYDROCORTISONE DIESTERS | Beiersdorf Aktiengesellschaft (DE) | 1990-09-12 | — | — | EP | claimed |
| EP-0217146-A2 | W/O creams containing hydrocortisone diesters | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | claimed |
| EP-0217141-A2 | W/O creams containing 17-propionate-21-acetate | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | claimed |