Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.88 |
| ▸ | AR | P10275 | 2/20 | 0.88 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.88 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.82 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285507 | 1.00 | PGR (0.88) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL605474 | 0.95 | NR3C2 (0.85) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL17219849 | 0.94 | PGR (0.80) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL4280673 | 0.94 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL4290122 | 0.94 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| SCHEMBL604267 | 0.94 | PGR (0.80) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL4778 | 0.94 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL14339602 | 0.94 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Probutate SCHEMBL30507561 | 0.94 | PGR (0.82) | PGRARCHRM1NR3C2NR3C1 | |
| Hydrocortisone Aceponate SCHEMBL3697 | 0.94 | PGR (1.00) | PGRARCHRM1NR3C2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4902682-A | W/O cream containing hydrocortisone diester | BEIERSDORF AG (DE) | 1990-02-20 | — | — | US | claimed |
| EP-0217146-A2 | W/O creams containing hydrocortisone diesters | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | claimed |
| EP-0217141-A2 | W/O creams containing 17-propionate-21-acetate | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | claimed |
| US-20090233892-A1 | Topical Compositions Comprising Hydrocortisone Butyrate | GLENMARK GENERICS LTD (IN) | 2009-09-17 | — | — | US | disclosed |
| US-5023251-A | Storage stability; skin disorders | BEIERSDORF AG (DE) | 1991-06-11 | — | — | US | disclosed |
| US-4902682-A | W/O cream containing hydrocortisone diester | BEIERSDORF AG (DE) | 1990-02-20 | — | — | US | disclosed |
| EP-0217146-A2 | W/O creams containing hydrocortisone diesters | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | disclosed |
| EP-0217141-A2 | W/O creams containing 17-propionate-21-acetate | Beiersdorf Aktiengesellschaft (DE) | 1987-04-08 | — | — | EP | disclosed |