Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10225814 | 0.81 | SCN9A (0.58) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL10177401 | 0.81 | SCN9A (0.84) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL4486162 | 0.81 | KCNH2 (0.58) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL867999 | 0.81 | KCNH2 (0.58) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL13713315 | 0.81 | KCNH2 (0.58) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL13729887 | 0.80 | MEN1 (0.64) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL1741981 | 0.79 | KCNH2 (0.55) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL2864184 | 0.78 | CYP2C19 (0.56) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL22628094 | 0.78 | NPC1 (0.45) | KCNH2SCN5ASCN9AMEN1KMT2A | |
| SCHEMBL19575358 | 0.78 | AURKA (0.57) | KCNH2SCN5ASCN9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9192577-B2 | Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-24 | — | — | US | disclosed |
| US-8809343-B2 | Pyrimidine derivative, preparation method and use thereof | FUDAN UNIVERSITY (CN) | 2014-08-19 | — | — | US | disclosed |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
| US-8101752-B2 | Process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)amino]benzonitrile | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-01-24 | — | — | US | disclosed |
| US-8080551-B2 | HIV inhibiting pyrimidines derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-12-20 | — | — | US | disclosed |
| US-20080171878-A1 | Process for Preparing 4-[(1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Amino]Benzonitrile | JANSSEN SCIENCES IRELAND UC (IE) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171878-A1 | Process for Preparing 4-[(1,6-Dihydro-6-Oxo-2-Pyrimidinyl)Amino]Benzonitrile | ME1, ALKBH1, DPYD | KCNH2 985/4885SCN5A 2879/4885SCN9A 2721/4885 |
| US-20120122902-A1 | PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | DPYD, TYMP, TYMS | KCNH2 2717/4885SCN5A 3258/4885SCN9A 4236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.