Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.50 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28610259 | 0.82 | SYK (0.51) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL21914834 | 0.81 | CTSK (0.58) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL27818985 | 0.80 | AURKA (0.39) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL27637976 | 0.79 | SYK (0.56) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL16227778 | 0.79 | ABCG2 (0.57) | MEN1KMT2AABCG2ABCB1KDR | |
| SCHEMBL3697392 | 0.79 | KCNH2 (0.58) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL13713315 | 0.79 | KCNH2 (0.58) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL4486162 | 0.79 | KCNH2 (0.58) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL867999 | 0.79 | KCNH2 (0.58) | KCNH2SCN5ASCN9ASYKMEN1 | |
| SCHEMBL10177401 | 0.79 | SCN9A (0.84) | KCNH2SCN5ASCN9ASYKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853567-B1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | JANSSEN R & D IRELAND (IE) | 2014-12-31 | — | — | EP | disclosed |
| WO-2014072419-A1 | NOVEL ANTI-HIV COMPOUNDS | UNIVERSITEIT ANTWERPEN (BE) | 2014-05-15 | — | — | WO | disclosed |
| CN-101107234-B | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives | TIBOTEC PHARM LTD | 2013-06-19 | — | — | CN | disclosed |
| CN-101107234-B | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives | TIBOTEC PHARM LTD | 2013-06-19 | — | — | CN | disclosed |
| EP-2388249-A1 | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives | Tibotec Pharmaceuticals (IE) | 2011-11-23 | — | — | EP | disclosed |
| US-20110255174-A1 | Display Device with an Optical Combiner Corrected for Chromatic Aberrations | THALES (FR) | 2011-10-20 | — | — | US | disclosed |
| EP-1853568-B1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO)PYRIMIDINE DERIVATIVES | TIBOTEC PHARM LTD (IE) | 2011-09-07 | — | — | EP | disclosed |
| US-20090124644-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
| CN-101107234-A | HIV inhibiting 2-(4-cyanophenylamino) pyrimidine derivatives | TIBOTEC PHARM LTD (IE) | 2008-01-16 | — | — | CN | disclosed |
| EP-1853568-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-11-14 | — | — | EP | disclosed |
| EP-1853568-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-11-14 | — | — | EP | disclosed |
| EP-1853567-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006087387-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-08-24 | — | — | WO | disclosed |
| WO-2006079656-A1 | HIV INHIBITING 2-( 4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-08-03 | — | — | WO | disclosed |
| WO-2006079656-A1 | HIV INHIBITING 2-( 4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2006-08-03 | — | — | WO | disclosed |
| CN-1234347-C | Anti-virus composition | JANSSEN PHARMACEUTICA NV (BE) | 2006-01-04 | — | — | CN | disclosed |
| US-6762205-B1 | STEROID SULFATASE INHIBITORS WITHOUT ESTROGENIC SIDE EFFECT ACTION | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 2004-07-13 | — | — | US | disclosed |
| CN-1376057-A | Anti-virus composition | JANSSEN PHARMACEUTICA NV (BE) | 2002-10-23 | — | — | CN | disclosed |
| EP-1193250-A1 | PHENYL SULFAMATE DERIVATIVES | Teikoku Hormone Mfg. Co., Ltd. (JP) | 2002-04-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124644-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | NR4A3, NR4A1, NR4A2 | KCNH2 4691/4885SCN5A 2496/4885SCN9A 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.