Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 7/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | RARA | P10276 | 6/20 | 0.61 |
| ▸ | RXRA | P19793 | 5/20 | 0.61 |
| ▸ | RARB | P10826 | 4/20 | 0.61 |
| ▸ | RARG | P13631 | 4/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.61 |
| ▸ | RXRB | P28702 | 2/20 | 0.61 |
| ▸ | RXRG | P48443 | 2/20 | 0.61 |
| ▸ | RORC | P51449 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | HTR2B | P41595 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 2/20 | 0.61 |
| ▸ | SNCA | P37840 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129368 | 1.00 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL3699677 | 1.00 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL3129371 | 1.00 | ALDH1A1 (0.76) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL9639452 | 0.89 | ALDH1A1 (0.69) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL23356521 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL3500196 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1718341 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL1718339 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL7127846 | 0.86 | ALDH1A1 (1.00) | ALDH1A1MAPTSMN1; SMN2RARARXRA | |
| SCHEMBL21140941 | 0.85 | ALDH1A1 (0.80) | ALDH1A1MAPTSMN1; SMN2RARARXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122908-A1 | Novel C-4 Substituted Retinoids | UNIVERSITY OF MARYLAND (US) | 2012-05-17 | — | — | US | disclosed |
| US-7265143-B2 | C-4 substituted retinoids | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1305274-A4 | NOVEL C-4 SUBSTITUTED RETINOIDS | UNIV MARYLAND (US) | 2005-10-12 | — | — | EP | disclosed |
| US-20030162823-A1 | Retinoids such as 4-(1H-imidazol-1-yl)-13-methylretinoate and/or isomers, administered for prophylaxis cancers and skin disorders | UNIVERSITY OF MARYLAND | 2003-08-28 | — | — | US | disclosed |
| EP-1305274-A2 | NOVEL C-4 SUBSTITUTED RETINOIDS | University of Maryland, Baltimore (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002003912-A2 | NOVEL C-4 SUBSTITUTED RETINOIDS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122908-A1 | Novel C-4 Substituted Retinoids | RARA, RARB, RARG | ALDH1A1 113/4885MAPT 4860/4885SMN1; SMN2 3651/4885 |
| US-20030162823-A1 | Retinoids such as 4-(1H-imidazol-1-yl)-13-methylretinoate and/or isomers, administered for prophylaxis cancers and skin disorders | RARA, RARB, RARG | ALDH1A1 73/4885MAPT 4870/4885SMN1; SMN2 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.