Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 5/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CLK2 | P49760 | 3/20 | 0.38 |
| ▸ | BLK | P51451 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700265 | 0.87 | MTNR1A (0.44) | AAK1MTNR1AMTNR1BDYRK1ACLK1 | |
| SCHEMBL3707415 | 0.86 | BRAF (0.52) | AAK1DYRK1ACLK1MAP3K11PAK1 | |
| SCHEMBL3697175 | 0.84 | BRAF (0.49) | DYRK1ACLK1MAP3K11PAK1CYP2C9 | |
| SCHEMBL3711724 | 0.84 | AAK1 (0.55) | AAK1MTNR1AMTNR1BDYRK1AMAP3K11 | |
| SCHEMBL3505473 | 0.84 | BRAF (0.52) | AAK1DYRK1ACLK1MAP3K11PAK1 | |
| SCHEMBL2356427 | 0.82 | BRAF (0.50) | CLK1PAK1CYP2D6CYP2C9BRAF | |
| SCHEMBL3507600 | 0.82 | AAK1 (0.46) | AAK1MTNR1AMTNR1BPAK1CYP2D6 | |
| SCHEMBL3504120 | 0.80 | BRAF (0.54) | AAK1DYRK1AMAP3K11PAK1CYP2C9 | |
| SCHEMBL3711232 | 0.79 | CAMKK2 (0.54) | DYRK1AAXLBRAFFESCSF1R | |
| SCHEMBL298805 | 0.79 | CYP2C9 (0.50) | CLK1PAK1CYP2D6CYP2C9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | AAK1 247/4885MTNR1A 3999/4885MTNR1B 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.