Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.30 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4120953 | 0.88 | MAPT (0.34) | HTR2CSLC6A4HTR2ACNR2MAPT | |
| SCHEMBL3692821 | 0.85 | HTR2C (0.49) | HTR2CSLC6A4HTR2ASLC16A3SLC16A1 | |
| SCHEMBL3699694 | 0.83 | HTR2C (0.45) | HTR2CSLC6A4HTR2ACNR2RIPK1 | |
| SCHEMBL3700345 | 0.82 | MAPT (0.32) | CNR2MAPT | |
| SCHEMBL3805129 | 0.81 | HTR2C (0.45) | HTR2CSLC6A4HTR2AMAPT | |
| SCHEMBL3690712 | 0.79 | HTR2C (0.45) | HTR2CSLC6A4HTR2ACNR2SLC16A3 | |
| SCHEMBL3693917 | 0.78 | RIPK1 (0.32) | MAPTRIPK1HTT | |
| SCHEMBL3700342 | 0.77 | RIPK1 (0.32) | CNR2MAPTRIPK1 | |
| SCHEMBL4120959 | 0.76 | MAPT (0.34) | CNR2MAPTRIPK1 | |
| SCHEMBL3701837 | 0.76 | HTR2C (0.43) | HTR2CSLC6A4HTR2ACNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |