Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2164753 | 0.81 | XDH (0.44) | KDM4EALDH1A1HPGDMAPTGABRA1 | |
| SCHEMBL9447454 | 0.80 | AR (0.38) | ALDH1A1LMNAGABRA1GABRB2L3MBTL1 | |
| SCHEMBL29135915 | 0.79 | AR (0.41) | ALDH1A1HPGDCYP3A4TP53ALOX15 | |
| SCHEMBL15321939 | 0.79 | KDM4E (0.42) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL29135913 | 0.79 | MAOB (0.46) | GABRA1GABRB2MAOAMAOB | |
| SCHEMBL1982932 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL13167760 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL14394001 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1USP2LMNAHPGD | |
| SCHEMBL30215694 | 0.76 | KLF10 (0.38) | GABRA1GABRB2 | |
| SCHEMBL29135911 | 0.76 | POLB (0.59) | KDM4EALDH1A1HPGDGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593461-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009309-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-19 | — | — | WO | disclosed |