Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1155049 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL12469892 | 0.94 | — | — | |
| SCHEMBL29270038 | 0.81 | CA5B (0.55) | — | |
| SCHEMBL11515499 | 0.81 | CA5B (0.55) | — | |
| SCHEMBL175234 | 0.81 | TDP1 (0.46) | — | |
| SCHEMBL3406422 | 0.80 | — | — | |
| SCHEMBL1332569 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL6872043 | 0.78 | ALDH1A1 (0.42) | — | |
| SCHEMBL3281043 | 0.77 | — | — | |
| SCHEMBL627424 | 0.76 | PAOX (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8603468-B2 | Neutralization of HCV | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-12-10 | — | — | US | disclosed |
| US-20100247522-A1 | LINKED PURINE PTERIN HPPK INHIBITORS USEFUL AS ANTIBACTERIAL AGENTS | THE GOV. OF THE U.S.A AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES | 2010-09-30 | — | — | US | disclosed |
| WO-2009061739-A1 | NEUTRALIZATION OF HCV | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2009-05-14 | — | — | WO | disclosed |
| EP-0509656-B1 | Compositions of phytosterols and phytosterolins as immunmodulators | ROOPEROL NA NV (NL) | 1996-09-18 | — | — | EP | disclosed |
| US-5486510-A | Method and compositions for modulating or control of immune responses in humans | ROOPEROL (NA) NV (NL) | 1996-01-23 | — | — | US | disclosed |
| EP-0141783-B2 | IMMUNE RESPONSE TO TUMOURS AND VIRUSES INDUCED BY ANTI-IDIOTYPE ANTIBODIES | THE WISTAR INSTITUTE (US) | 1993-06-16 | — | — | EP | disclosed |
| EP-0509656-A1 | Compositions of phytosterols and phytosterolins as immunmodulators | ROOPEROL (NA) NV (NL) | 1992-10-21 | — | — | EP | disclosed |
| US-5053224-A | Induction of antibody response to solid tumors with anti-idiotype antibodies | KOPROWSKI HILARY (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0141783-B1 | IMMUNE RESPONSE TO TUMOURS AND VIRUSES INDUCED BY ANTI-IDIOTYPE ANTIBODIES | THE WISTAR INSTITUTE (US) | 1989-08-09 | — | — | EP | disclosed |
| WO-1985002121-A1 | IMMUNE RESPONSE TO TUMORS AND VIRUSES INDUCED BY ANTI-IDIOTYPE ANTIBODIES | THE WISTAR INSTITUTE (US) | 1985-05-23 | — | — | WO | disclosed |
| EP-0141783-A2 | Immune response to tumours and viruses induced by anti-idiotype antibodies | THE WISTAR INSTITUTE (US) | 1985-05-15 | — | — | EP | disclosed |