Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701125 | 0.93 | LPAR1 (0.40) | LPAR1LPAR2LPAR3PTGDR2FFAR1 | |
| SCHEMBL2338262 | 0.91 | LPAR1 (0.50) | LPAR1LPAR2LPAR3NR1H4PPARD | |
| SCHEMBL3704161 | 0.89 | LPAR1 (0.47) | LPAR1LPAR2LPAR3NR1H4PPARD | |
| SCHEMBL3707791 | 0.89 | LPAR1 (0.38) | LPAR1LPAR2LPAR3PTGDR2MAPT | |
| SCHEMBL3700609 | 0.88 | LPAR1 (0.46) | LPAR1LPAR2LPAR3PTGDR2NR1H4 | |
| SCHEMBL1247804 | 0.87 | NPSR1 (0.37) | LPAR1LPAR2LPAR3PTGDR2MAPT | |
| SCHEMBL3702563 | 0.85 | NR1H4 (0.46) | LPAR1LPAR2LPAR3PTGDR2FFAR1 | |
| SCHEMBL3714465 | 0.85 | LPAR1 (0.45) | LPAR1LPAR2LPAR3FFAR1NR1H4 | |
| SCHEMBL3712765 | 0.85 | LPAR1 (0.43) | LPAR1LPAR2LPAR3PTGDR2MAPT | |
| SCHEMBL3702333 | 0.84 | LPAR1 (0.44) | LPAR1LPAR2LPAR3FFAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |