Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9902333 | 0.92 | ALDH1A1 (0.35) | NPSR1NR1H4GPBAR1POLBMAPT | |
| SCHEMBL1245358 | 0.91 | NR1H4 (0.42) | NR1H4PTGS2GPBAR1POLBMAPT | |
| SCHEMBL1245176 | 0.89 | NR1H4 (0.40) | NR1H4GPBAR1POLBMAPTALDH1A1 | |
| SCHEMBL1246186 | 0.89 | PTGDR2 (0.38) | NPSR1GPBAR1POLBMAPTALDH1A1 | |
| SCHEMBL1246477 | 0.88 | NR1H4 (0.42) | NR1H4GPBAR1MAPTALDH1A1PPARD | |
| SCHEMBL3701141 | 0.87 | LPAR1 (0.43) | NPSR1NR1H4RORCMAPTALDH1A1 | |
| SCHEMBL1246467 | 0.86 | NR1H4 (0.43) | NR1H4PTGS2GPBAR1PPARDLPAR1 | |
| SCHEMBL1245335 | 0.85 | NR1H4 (0.50) | NR1H4MAPTPPARD | |
| SCHEMBL1246476 | 0.85 | NR1H4 (0.42) | NR1H4GPBAR1MAPTALDH1A1PPARD | |
| SCHEMBL1246346 | 0.84 | SCN9A (0.38) | NR1H4GPBAR1MAPTALDH1A1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |