Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP16 | P51512 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701141 | 0.89 | LPAR1 (0.43) | LPAR1LPAR2LPAR3PTGDR2NPSR1 | |
| SCHEMBL3709238 | 0.89 | LPAR1 (0.41) | LPAR1LPAR2LPAR3PTGDR2NPSR1 | |
| SCHEMBL1246186 | 0.88 | PTGDR2 (0.38) | PTGDR2NPSR1POLBTP53MAPT | |
| SCHEMBL3701125 | 0.87 | LPAR1 (0.40) | LPAR1LPAR2LPAR3PTGDR2TP53 | |
| SCHEMBL3704161 | 0.86 | LPAR1 (0.47) | LPAR1LPAR2LPAR3 | |
| SCHEMBL2338262 | 0.86 | LPAR1 (0.50) | LPAR1LPAR2LPAR3 | |
| SCHEMBL2342592 | 0.85 | LPAR1 (0.39) | LPAR1LPAR2LPAR3POLBSLC26A6 | |
| SCHEMBL3703134 | 0.84 | LPAR1 (0.39) | LPAR1LPAR2LPAR3PTGDR2SLC26A6 | |
| SCHEMBL3707308 | 0.84 | CFD (0.40) | LPAR1LPAR2LPAR3NPSR1HPGD | |
| SCHEMBL3700609 | 0.83 | LPAR1 (0.46) | LPAR1LPAR2LPAR3PTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |