Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6066440 | 0.82 | AAK1 (0.44) | AKT1CDK2SMYD3 | |
| SCHEMBL27600626 | 0.80 | AKT1 (0.41) | AKT1CDK2SMYD3 | |
| SCHEMBL1729045 | 0.77 | F11 (0.45) | AKT1CDK2SMYD3 | |
| SCHEMBL1728006 | 0.75 | P4HTM (0.37) | AKT1CDK2SMYD3 | |
| SCHEMBL1728827 | 0.75 | SMYD3 (0.44) | AKT1CDK2SMYD3 | |
| SCHEMBL27655008 | 0.74 | SLC6A4 (0.35) | AKT1CDK2 | |
| SCHEMBL4071612 | 0.73 | SMYD3 (0.60) | AKT1CDK2SMYD3 | |
| SCHEMBL1727781 | 0.73 | SMYD3 (0.43) | AKT1CDK2SMYD3 | |
| SCHEMBL673132 | 0.71 | CYP19A1 (0.37) | AKT1 | |
| SCHEMBL30749440 | 0.71 | CYP19A1 (0.37) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201012-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | AstraZeneca AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009047563-A1 | PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |