⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701383 | 0.83 | PDE4D (0.30) | — | |
| SCHEMBL3706403 | 0.80 | — | — | |
| SCHEMBL3707537 | 0.76 | SYK (0.30) | — | |
| SCHEMBL3709051 | 0.73 | TBK1 (0.37) | — | |
| SCHEMBL3703993 | 0.69 | CDC7 (0.42) | — | |
| SCHEMBL3708764 | 0.69 | F2RL1 (0.32) | — | |
| SCHEMBL22778051 | 0.68 | DGAT1 (0.36) | — | |
| SCHEMBL29714404 | 0.68 | DGAT1 (0.36) | — | |
| SCHEMBL3703721 | 0.68 | JAK2 (0.36) | — | |
| SCHEMBL22777981 | 0.66 | ADRA2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551981-B2 | Furo[3,2-d]pyrimidine compounds | ABBVIE INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |