Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30121999 | 1.00 | MAPT (0.51) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7763921 | 0.91 | MAPT (0.46) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL10545783 | 0.85 | DRD4 (0.48) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL9066974 | 0.84 | KDM4E (0.51) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL7168254 | 0.84 | HSPB1 (0.45) | MAPTKMT2ALMNAPKMPRMT5 | |
| SCHEMBL5937140 | 0.84 | PRMT5 (0.49) | LMNAPKMPRMT5WDR77ALDH1A1 | |
| SCHEMBL20761098 | 0.84 | TDP1 (0.54) | MAPTMEN1KMT2ALMNAPKM | |
| SCHEMBL5963778 | 0.84 | S1PR4 (0.52) | MAPTKMT2ALMNAPKMPRMT5 | |
| SCHEMBL12835342 | 0.84 | MAPT (0.51) | MAPTMEN1KMT2AKDM4ELMNA | |
| SCHEMBL8488406 | 0.84 | CHEK1 (0.48) | MAPTMEN1KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3670500-A1 | CHEMICAL COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE AND APPLICATION THEREOF | Beijing Hanmi Pharmaceutical Co., Ltd. (CN) | 2020-06-24 | — | — | EP | disclosed |
| EP-3670500-A1 | CHEMICAL COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF, AND USE AND APPLICATION THEREOF | Beijing Hanmi Pharmaceutical Co., Ltd. (CN) | 2020-06-24 | — | — | EP | disclosed |
| US-20200172529-A1 | Chemical Compound, Pharmaceutical Composition Thereof, and Use and Application Thereof | BEIJING HANMI PHARM. CO., LTD. (CN) | 2020-06-04 | — | — | US | disclosed |
| US-20200172529-A1 | Chemical Compound, Pharmaceutical Composition Thereof, and Use and Application Thereof | BEIJING HANMI PHARM. CO., LTD. (CN) | 2020-06-04 | — | — | US | disclosed |
| US-9101634-B2 | Application of 2, 3-dihydro-3-hydroxymethyl-6-amino-[1,4]-benzoxazine in preparation of drugs inducing embryonic stem cells to differentiate to vascular endothelial cells | SHANDONG UNIVERSITY (CN) | 2015-08-11 | — | — | US | disclosed |
| US-20120123116-A1 | APPLICATION OF 2, 3 - DIHYDRO-3 - HYDROXYMETHYL -6 - AMINO - [1,4 ] - BENZOXAZINE IN PREPARATION OF DRUGS INDUCING EMBRYONIC STEM CELLS TO DIFFERENTIATE TO VASCULAR ENDOTHELIAL CELLS | SHANDONG UNIVERSITY (CN) | 2012-05-17 | — | — | US | disclosed |
| US-4123614-A | USED IN DETECTION AND MEASUREMENT OF BIOLOGICAL SYSTEMS AND/OR COMPONENTS | SYNTEX (U.S.A.) INC. (US) | 1978-10-31 | — | — | US | disclosed |
| US-4070415-A | Thermoplastic molding compositions on the basis of polyoxymethylenes | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-01-24 | — | — | US | disclosed |
| US-3980734-A | Thermoplastic moulding compositions based on poly (oxymethylene) | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123116-A1 | APPLICATION OF 2, 3 - DIHYDRO-3 - HYDROXYMETHYL -6 - AMINO - [1,4 ] - BENZOXAZINE IN PREPARATION OF DRUGS INDUCING EMBRYONIC STEM CELLS TO DIFFERENTIATE TO VASCULAR ENDOTHELIAL CELLS | EDF1, CBX6, MCL1 | MAPT 4645/4885MEN1 4815/4885KMT2A 621/4885 |
| US-20200172529-A1 | Chemical Compound, Pharmaceutical Composition Thereof, and Use and Application Thereof | SYK, JAK1, JAK2 | MAPT 335/4885MEN1 3038/4885KMT2A 1231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.