Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 3/20 | 0.47 |
| ▸ | CES1 | P23141 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL316378 | 0.81 | TSHR (0.48) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| Benzene SCHEMBL27641543 | 0.80 | TSHR (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL26712 | 0.80 | TSHR (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL146504 | 0.80 | TSHR (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL28197933 | 0.80 | TSHR (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL5245130 | 0.78 | CES2 (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL34992 | 0.78 | CES2 (0.52) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL2598221 | 0.78 | MAPT (0.53) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL2231539 | 0.77 | TSHR (0.48) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL4303850 | 0.77 | TSHR (0.48) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0123441-B1 | VINCALEUKOBLASTINE DERIVATIVES | LILLY INDUSTRIES LIMITED (GB) | 1990-10-03 | — | — | EP | claimed |
| US-4675400-A | FORM CONJUGATES WITH IMMUNOGLOBULINS; ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1987-06-23 | — | — | US | claimed |
| US-4596676-A | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids | LILLY INDUSTRIES LIMITED (GB) | 1986-06-24 | — | — | US | claimed |
| EP-0123441-A1 | Vincaleukoblastine derivatives | LILLY INDUSTRIES LIMITED (GB) | 1984-10-31 | — | — | EP | claimed |
| EP-2396017-A1 | APOLIPOPROTEIN A-I MIMICS | Cerenis Therapeutics SA (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010093918-A1 | APOLIPOPROTEIN A-I MIMICS | CERENIS THERAPEUTICS SA (FR) | 2010-08-19 | — | — | WO | disclosed |
| EP-0123441-B1 | VINCALEUKOBLASTINE DERIVATIVES | LILLY INDUSTRIES LIMITED (GB) | 1990-10-03 | — | — | EP | disclosed |
| US-4675400-A | FORM CONJUGATES WITH IMMUNOGLOBULINS; ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| US-4596676-A | Bifunctional ester derivatives of 4-desacetyl indole-dihydroindole alkaloids | LILLY INDUSTRIES LIMITED (GB) | 1986-06-24 | — | — | US | disclosed |
| EP-0123441-A1 | Vincaleukoblastine derivatives | LILLY INDUSTRIES LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |