Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335475 | 0.94 | KDM4E (0.39) | KDM4ETP53ALDH1A1LPAR1HDAC4 | |
| SCHEMBL3702315 | 0.93 | LPAR1 (0.40) | KDM4ETP53LPAR1TSHRLMNA | |
| SCHEMBL3701871 | 0.93 | KDM4E (0.34) | KDM4ETP53SMN1; SMN2TSHRLMNA | |
| SCHEMBL3715778 | 0.92 | KDM4E (0.38) | KDM4ETP53ALDH1A1LPAR1HDAC4 | |
| SCHEMBL3702204 | 0.90 | TP53 (0.38) | KDM4ETP53ALDH1A1LPAR1HDAC4 | |
| SCHEMBL3706580 | 0.89 | MMP2 (0.36) | KDM4ETP53TSHRKMT2AUSP2 | |
| SCHEMBL3705660 | 0.88 | SYK (0.35) | KDM4ETP53ALDH1A1LPAR1HDAC4 | |
| SCHEMBL3708579 | 0.87 | MBOAT4 (0.33) | KDM4ETP53LPAR1SMN1; SMN2LMNA | |
| SCHEMBL2335539 | 0.87 | LPAR1 (0.45) | KDM4ETP53LPAR1TSHRLMNA | |
| SCHEMBL3704734 | 0.86 | KDM4E (0.35) | KDM4ETP53ALDH1A1LPAR1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |