Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.36 |
| ▸ | MMP9 | P14780 | 4/20 | 0.36 |
| ▸ | MMP12 | P39900 | 4/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704746 | 0.93 | MMP2 (0.44) | MMP2MMP9MMP12MMP14TP53 | |
| SCHEMBL3703091 | 0.89 | KDM4E (0.36) | TP53MAPTSLC26A6KDM4EKMT2A | |
| SCHEMBL3701871 | 0.87 | KDM4E (0.34) | TP53MAPTKDM4EKMT2APOLB | |
| SCHEMBL2335475 | 0.84 | KDM4E (0.39) | TP53MAPTSLC26A6KDM4EKMT2A | |
| SCHEMBL3702315 | 0.84 | LPAR1 (0.40) | TP53MAPTSLC26A6KDM4EPOLB | |
| SCHEMBL3715778 | 0.83 | KDM4E (0.38) | TP53MAPTKDM4EKMT2APOLB | |
| SCHEMBL3706560 | 0.82 | KDM4E (0.36) | TP53MAPTKDM4EPOLBNPSR1 | |
| SCHEMBL3702204 | 0.81 | TP53 (0.38) | TP53MAPTKDM4EKMT2AHPGD | |
| SCHEMBL3708489 | 0.80 | TP53 (0.35) | TP53MAPTSLC26A6KDM4EKMT2A | |
| SCHEMBL3705660 | 0.80 | SYK (0.35) | TP53KDM4EKMT2APOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |