Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 9/20 | 0.51 |
| ▸ | DRD4 | P21917 | 9/20 | 0.51 |
| ▸ | DRD3 | P35462 | 9/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3870053 | 0.83 | OPRL1 (0.55) | OPRL1ACHEOPRM1DRD2DRD4 | |
| Lithium Ion SCHEMBL3864715 | 0.80 | OPRL1 (0.52) | OPRL1ACHEOPRM1DRD2DRD4 | |
| SCHEMBL3063295 | 0.79 | CHRM3 (0.59) | OPRL1ACHEOPRM1DRD2DRD4 | |
| SCHEMBL11217794 | 0.77 | OPRL1 (0.57) | OPRL1ACHEOPRM1DRD2DRD4 | |
| SCHEMBL17803176 | 0.75 | OPRL1 (0.53) | OPRL1ACHEOPRM1DRD2DRD4 | |
| SCHEMBL156315 | 0.72 | ACHE (1.00) | ACHEDRD2DRD4DRD3 | |
| SCHEMBL31437068 | 0.72 | CHRM3 (0.61) | OPRL1OPRM1DRD2DRD4DRD3 | |
| SCHEMBL3073412 | 0.72 | OPRL1 (0.60) | OPRL1ACHEOPRM1DRD2DRD4 | |
| SCHEMBL11098844 | 0.72 | OPRL1 (1.00) | OPRL1OPRM1DRD2DRD4DRD3 | |
| SCHEMBL7474059 | 0.71 | SMN1; SMN2 (0.56) | ACHEDRD2DRD4DRD3RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091411-A1 | PIPERIDINYL CYCLIC AMIDO ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2010-08-12 | — | — | WO | disclosed |
| US-4242347-A | Hypotensive indolylalkylpiperidyl guanidines and isoureas | CIBA-GEIGY CORPORATION (US) | 1980-12-30 | — | — | US | disclosed |
| US-4147786-A | HYPOTENSIVE | CIBA-GEIGY CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |
| US-4073911-A | ANTIHYPERTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-14 | — | — | US | disclosed |