Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | GRN | P28799 | 2/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244570 | 0.90 | GCK (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1741637 | 0.86 | ALDH1A1 (0.34) | GCK | |
| SCHEMBL1741636 | 0.86 | ALDH1A1 (0.34) | GCK | |
| SCHEMBL1740197 | 0.79 | GCK (0.54) | GCK | |
| SCHEMBL3017083 | 0.78 | GCK (0.48) | GCK | |
| SCHEMBL3702379 | 0.78 | GCK (0.46) | GCK | |
| SCHEMBL3017123 | 0.78 | GCK (0.48) | GCK | |
| SCHEMBL23256558 | 0.75 | PSEN1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13244571 | 0.72 | GCK (0.41) | GCKKMT2ASMN1; SMN2LMNA | |
| SCHEMBL21459640 | 0.72 | ALDH1A1 (0.38) | GCKSMN1; SMN2MCL1BCL2BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010084428-A1 | SUBSTITUTED PYRAZINONE AMIDES | PFIZER INC. (US) | 2010-07-29 | — | — | WO | disclosed |