Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13385220 | 0.75 | SLC6A2 (0.38) | HTR2AHTR2CHTR2BSLC6A2SLC6A3 | |
| SCHEMBL20910798 | 0.72 | SLC6A2 (0.36) | HTR2CSLC6A2SLC6A3NISCHAADAT | |
| SCHEMBL3703566 | 0.71 | SIRT1 (0.42) | SLC6A2SLC6A3NISCHSIRT1AADAT | |
| SCHEMBL16685210 | 0.68 | SLC22A12 (0.34) | HTR2AHTR2CHTR2BSLC6A2SLC6A3 | |
| SCHEMBL3216668 | 0.66 | NISCH (0.40) | HTR2AHTR2CHTR2BNISCHSIRT1 | |
| SCHEMBL3216444 | 0.66 | NISCH (0.40) | HTR2AHTR2CHTR2BNISCHSIRT1 | |
| SCHEMBL3199621 | 0.66 | NISCH (0.40) | HTR2AHTR2CHTR2BNISCHSIRT1 | |
| SCHEMBL2685298 | 0.64 | CASR (0.49) | NISCHSIRT1CASR | |
| SCHEMBL8244323 | 0.64 | PRKACA (0.51) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL24305724 | 0.63 | AADAT (0.45) | HTR2AHTR2CHTR2BSLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122854-A1 | Carbocyclic Fused Cyclic Amines | BOEHRINGER MARKUS (CH) | 2012-05-17 | — | — | US | disclosed |
| EP-1948639-A2 | NOVEL CARBOCYCLIC FUSED CYCLIC AMINES | F. Hoffmann-la Roche AG (CH) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054453-A2 | CARBOCYCLIC FUSED CYCLIC AMINES AS INHIBITORS OF THE COAGULATION FACTOR XA | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-18 | — | — | WO | disclosed |
| US-20070112012-A1 | Carbocyclic fused cyclic amines | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112012-A1 | Carbocyclic fused cyclic amines | F12, F11, F2 | HTR2A 1196/4885HTR2C 776/4885HTR2B 433/4885 |
| US-20120122854-A1 | Carbocyclic Fused Cyclic Amines | F12, F11, F2 | HTR2A 1196/4885HTR2C 776/4885HTR2B 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.