Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | CATSPER1 | Q8NEC5 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656439 | 0.89 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL3655414 | 0.81 | ADORA2A (0.41) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL3707622 | 0.79 | ADORA1 (0.40) | ADORA2AADORA1ALDH1A1RAB9APOLB | |
| SCHEMBL13907139 | 0.76 | RAB9A (0.40) | ADORA2AADORA1ALDH1A1RAB9APOLB | |
| SCHEMBL3651671 | 0.75 | ADORA2A (0.61) | ADORA2AADORA1 | |
| SCHEMBL3748897 | 0.73 | ALDH1A1 (0.41) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL3715474 | 0.71 | ADORA2A (0.44) | ADORA2AADORA1ALDH1A1NPSR1HTT | |
| SCHEMBL3657664 | 0.70 | ADORA2A (0.38) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL3655720 | 0.70 | ADORA2A (0.41) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 | |
| SCHEMBL6859325 | 0.70 | ADORA2A (0.49) | ADORA2AADORA1ALDH1A1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305143-A1 | PYRROLOPYRIMIDINE COMPOUNDS | VERNALIS (R & D) LTD. (GB) | 2010-12-02 | — | — | US | disclosed |
| US-20100305143-A1 | PYRROLOPYRIMIDINE COMPOUNDS | VERNALIS (R & D) LTD. (GB) | 2010-12-02 | — | — | US | disclosed |
| US-20100305143-A1 | PYRROLOPYRIMIDINE COMPOUNDS | VERNALIS (R & D) LTD. (GB) | 2010-12-02 | — | — | US | disclosed |
| EP-2203452-A1 | PYRROLOPYRIMIDINE COMPOUNDS | Vernalis (R&D) Ltd. (GB) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009037467-A1 | PYRROLOPYRIMIDINE COMPOUNDS | VERNALIS (R & D) LTD. (GB) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037467-A1 | PYRROLOPYRIMIDINE COMPOUNDS | VERNALIS (R & D) LTD. (GB) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305143-A1 | PYRROLOPYRIMIDINE COMPOUNDS | ADORA2B, CNR2, CNR1 | ADORA2A 15/4885ADORA1 39/4885ALDH1A1 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.