Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707040 | 0.86 | ROCK1 (0.37) | ROCK1GAAMAPT | |
| SCHEMBL3651913 | 0.84 | BCL9 (0.41) | RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL3653649 | 0.84 | BCL9 (0.41) | RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL3658188 | 0.84 | BCL9 (0.41) | RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL3657527 | 0.83 | RAB9A (0.46) | RAB9AKDM4EALDH1A1NPC1HPGD | |
| SCHEMBL3657254 | 0.82 | SMN1; SMN2 (0.39) | RAB9AALDH1A1NPC1MAPT | |
| SCHEMBL3654285 | 0.81 | MAPT (0.38) | RAB9AMAPT | |
| SCHEMBL3648133 | 0.80 | LMNA (0.41) | RAB9AKDM4EPOLBALDH1A1NPC1 | |
| SCHEMBL3657543 | 0.80 | NPC1 (0.40) | RAB9AKDM4EALDH1A1NPC1ROCK2 | |
| SCHEMBL3655567 | 0.79 | MAPT (0.33) | RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |