Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.54 |
| ▸ | AKT2 | P31751 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708211 | 0.85 | AKT1 (0.54) | AKT1AKT2ALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL3706568 | 0.79 | AKT1 (0.50) | AKT1AKT2ALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL17644703 | 0.73 | AKT1 (0.43) | AKT1AKT2ALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL13256523 | 0.71 | AKT1 (0.79) | AKT1AKT2 | |
| SCHEMBL2969936 | 0.67 | AKT1 (0.39) | AKT1AKT2ALDH1A1MAPT | |
| SCHEMBL3804796 | 0.67 | TGFBR1 (0.41) | AKT1AKT2ALDH1A1HSD17B10HPGD | |
| SCHEMBL16897424 | 0.66 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL25367703 | 0.66 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL2973681 | 0.66 | AKT1 (0.49) | AKT1AKT2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29694746 | 0.65 | POLQ (0.42) | KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-B1 | FUSED PYRIMIDINES | BAYER IP GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-8957064-B2 | Fused pyrimidines | BAYER INTELLECTUAL PROPERTY GMBH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957064-B2 | Fused pyrimidines | BAYER INTELLECTUAL PROPERTY GMBH (US) | 2015-02-17 | — | — | US | disclosed |
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |