Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.50 |
| ▸ | AKT2 | P31751 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3804796 | 0.87 | TGFBR1 (0.41) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3709331 | 0.82 | AKT1 (0.50) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3704097 | 0.79 | AKT1 (0.54) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3713237 | 0.78 | KDM4E (0.48) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4507101 | 0.76 | KDM4E (0.46) | ALDH1A1HPGDHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL13606405 | 0.75 | KDM4E (0.46) | AKT1AKT2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL24501579 | 0.71 | POLQ (0.42) | KDM4ELMNAPOLB | |
| SCHEMBL29694746 | 0.71 | POLQ (0.42) | KDM4ELMNAPOLB | |
| SCHEMBL4512702 | 0.70 | KDM4E (0.43) | ALDH1A1HPGDHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL22105272 | 0.70 | TGFBR1 (0.48) | ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396330-A1 | FUSED PYRIMIDINES | Bayer Pharma Aktiengesellschaft (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091808-A1 | FUSED PYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-08-19 | — | — | WO | disclosed |