Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.58 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696020 | 1.00 | HSD11B1 (0.58) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL308000 | 0.87 | MMP1 (0.58) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL309347 | 0.87 | MMP1 (0.58) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL2170723 | 0.84 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL1430398 | 0.84 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL308001 | 0.84 | MMP1 (0.45) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL309348 | 0.84 | MMP1 (0.45) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL4943200 | 0.81 | L3MBTL1 (0.64) | MEN1KMT2A | |
| SCHEMBL2690125 | 0.81 | MMP1 (0.58) | HSD11B1MMP1MMP9MMP13MEN1 | |
| SCHEMBL2690128 | 0.81 | MMP1 (0.58) | HSD11B1MMP1MMP9MMP13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313413-B1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES | CONVERGENCE PHARMACEUTICALS (GB) | 2012-05-16 | — | — | EP | disclosed |