Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11353719 | 0.88 | CTSS (0.44) | CTSSCTSKS1PR3MAPTFOLH1 | |
| SCHEMBL3775563 | 0.86 | FOLH1 (0.50) | FOLH1 | |
| SCHEMBL16044610 | 0.82 | CTSK (0.41) | CTSSCTSKAAK1 | |
| SCHEMBL16044609 | 0.82 | CTSK (0.41) | CTSSCTSKAAK1 | |
| SCHEMBL1554122 | 0.82 | CTSS (0.48) | CTSSCTSKS1PR3KLK5MAPT | |
| SCHEMBL14254331 | 0.82 | CTSS (0.48) | CTSSCTSKS1PR3KLK5MAPT | |
| SCHEMBL2582580 | 0.82 | CTSS (0.48) | CTSSCTSKS1PR3KLK5MAPT | |
| SCHEMBL1554126 | 0.82 | CTSS (0.48) | CTSSCTSKS1PR3KLK5MAPT | |
| SCHEMBL3619414 | 0.80 | CTSS (0.47) | CTSSCTSKS1PR3KLK5MAPT | |
| SCHEMBL20752378 | 0.78 | AAK1 (0.40) | CTSSCTSKAAK1S1PR3KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217592-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009058300-A1 | BIPHENYL DERIVATIVES AS MODULATORS OF THE HISTAMINE-H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2009-05-07 | — | — | WO | disclosed |