Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3704734 | 0.93 | KDM4E (0.35) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL2335539 | 0.90 | LPAR1 (0.45) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL3712524 | 0.89 | LPAR1 (0.42) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL3709661 | 0.87 | LPAR1 (0.41) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL1246914 | 0.87 | KDM4E (0.39) | KDM4ETP53NPC1PTGER4NR1H4 | |
| SCHEMBL3702315 | 0.86 | LPAR1 (0.40) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL3708422 | 0.85 | KDM4E (0.40) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL2333912 | 0.85 | DGAT1 (0.41) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL3710544 | 0.85 | LPAR1 (0.42) | LPAR1KDM4ELPAR2LPAR3TP53 | |
| SCHEMBL2341053 | 0.84 | LPAR1 (0.42) | LPAR1KDM4ELPAR2LPAR3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |