Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708181 | 0.94 | KDM4E (0.38) | KDM4ELPAR1TP53ROCK2CA12 | |
| SCHEMBL2335539 | 0.87 | LPAR1 (0.45) | KDM4ELPAR1LPAR2LPAR3TP53 | |
| SCHEMBL1246372 | 0.87 | KDM4E (0.41) | KDM4EPPARDPPARGTP53NR1H4 | |
| SCHEMBL3709661 | 0.86 | LPAR1 (0.41) | KDM4ELPAR1LPAR2LPAR3PPARD | |
| SCHEMBL3712524 | 0.86 | LPAR1 (0.42) | KDM4ELPAR1LPAR2LPAR3TP53 | |
| SCHEMBL3705535 | 0.85 | LPAR1 (0.38) | KDM4ELPAR1LPAR2LPAR3PPARD | |
| SCHEMBL3707867 | 0.84 | KDM4E (0.40) | KDM4ELPAR1LPAR2LPAR3TP53 | |
| SCHEMBL3702315 | 0.83 | LPAR1 (0.40) | KDM4ELPAR1LPAR2LPAR3TP53 | |
| SCHEMBL2333912 | 0.82 | DGAT1 (0.41) | KDM4ELPAR1LPAR2LPAR3TP53 | |
| SCHEMBL2341053 | 0.81 | LPAR1 (0.42) | KDM4ELPAR1LPAR2LPAR3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |