Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247276 | 0.93 | KDM4E (0.37) | KDM4ENPC1SCN9ACACNA1FCACNA1D | |
| SCHEMBL1245270 | 0.90 | KDM4E (0.44) | KDM4ENPC1SCN9ANR1H4PPARD | |
| SCHEMBL3705535 | 0.87 | LPAR1 (0.38) | KDM4ENPC1NR1H4PPARDPTGER4 | |
| SCHEMBL1246372 | 0.85 | KDM4E (0.41) | KDM4ENPC1SCN9ANR1H4PPARD | |
| SCHEMBL1247748 | 0.85 | SCN9A (0.39) | SCN9ANR1H4PPARDGPBAR1PPARG | |
| SCHEMBL1247569 | 0.84 | SCN9A (0.39) | KDM4ENPC1SCN9ANR1H4PPARD | |
| SCHEMBL1247617 | 0.84 | NPC1 (0.38) | KDM4ENPC1SCN9APPARDCACNA1F | |
| SCHEMBL1245262 | 0.82 | THRB (0.37) | KDM4ENPC1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL1247624 | 0.82 | THRB (0.37) | KDM4ENPC1GPBAR1MEN1KMT2A | |
| SCHEMBL1247291 | 0.81 | SCN9A (0.41) | KDM4ENPC1SCN9ANR1H4PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |