Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.99 |
| ▸ | THRB | P10828 | 1/20 | 0.99 |
| ▸ | TSHR | P16473 | 1/20 | 0.99 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL9326569 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16091123 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL11522109 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL2222952 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL18061225 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16072819 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL15387468 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL3758644 | 0.99 | HSD17B10 (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL40452 | 0.99 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL28649126 | 0.99 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 26136 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747395-A1 | A KIT FOR IDENTIFYING BACTERIA AND DETERMINING ANTIBIOTIC SENSITIVITY | Diagopreutic Private Limited (IN) | 2026-05-27 | — | — | EP | claimed |
| US-12637481-B2 | Boronic acid derivatives and therapeutic uses thereof | QPEX BIOPHARMA, INC. (US) | 2026-05-26 | — | — | US | claimed |
| CN-122071712-A | Beta-lactam antibiotic whole-cell biosensor, construction method and application | 中国科学院天津工业生物技术研究所 | 2026-05-22 | — | — | CN | claimed |
| CN-122035989-A | Method for reducing runoff pollution load of river bank zone | 中国长江三峡集团有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-12622919-B2 | Methods for treating hypervirulent Klebsiella pneumoniae infection | CITY UNIVERSITY OF HONG KONG (CN) | 2026-05-12 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| EP-4725496-A2 | N-[4-[1-(1,4-DIOXASPIRO[4.5]DEC-8-YL)-4-(8-OXA-3-AZABICYCLO[3.2.1]OCT-3-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL]PHENYL]-N'-METHYLUREA FOR USE IN THE TREATMENT OF COVID19 | NantCell, Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12590108-B2 | Boracic acid compound | PHAENO THERAPEUTICS CO., LTD (CN) | 2026-03-31 | — | — | US | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| US-20260034183-A1 | TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION | VEDANTA BIOSCIENCES, INC. (US) | 2026-02-05 | — | — | US | claimed |
| US-4503040-A | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors | PFIZER INC. (US) | 1985-03-05 | — | — | US | claimed |
| EP-0118196-A1 | Process for the manufacture of highly crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-09-12 | — | — | EP | claimed |
| US-4458070-A | Process for the manufacture of crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-07-03 | — | — | US | claimed |
| US-4456753-A | Process for the manufacture of highly crystalline sodium cefoperazone | PFIZER INC. (US) | 1984-06-26 | — | — | US | claimed |
| US-4452796-A | ANTIBIOTICS | PFIZER INC. (US) | 1984-06-05 | — | — | US | claimed |
| EP-0101170-A1 | Process for the manufacture of sodium cefoperazone | PFIZER INC. (US) | 1984-02-22 | — | — | EP | claimed |
| US-4427678-A | 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1984-01-24 | — | — | US | claimed |
| EP-0084925-A1 | 6-Aminoalkylpenicillanic acid 1,1-dioxides and derivatives as beta-lactamase inhibitors | PFIZER INC. (US) | 1983-08-03 | — | — | EP | claimed |
| WO-1982003090-A1 | METHOD AND KIT FOR IDENTIFICATION OF BETA-LACTAMASES | JAMES RICHARD | 1982-09-16 | — | — | WO | claimed |
| EP-0059645-A1 | Method and kit for identification of beta-lactamases | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1982-09-08 | — | — | EP | claimed |