Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 10/20 | 0.99 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.99 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.99 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.99 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.99 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.87 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL15387468 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL37056 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL11522109 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL9326569 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL18061225 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL16091123 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL2222952 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL16072819 | 0.99 | MAPT (1.00) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL40452 | 0.99 | MAPT (0.99) | HSD17B10THRBTSHRMAPTSLC22A6 | |
| Cefoperazone SCHEMBL28649126 | 0.99 | MAPT (0.99) | HSD17B10THRBTSHRMAPTSLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4678512-A | Marine coating compositions and method | GRAMS RALPH R | 1987-07-07 | — | — | US | claimed |
| US-20220168384-A1 | Anti-Bacterial Combination Therapy | MCMASTER UNIVERSITY (CA) | 2022-06-02 | — | — | US | disclosed |
| CN-107037140-B | Method for efficiently detecting residual quantity of cephalosporin in aquatic product | 浙江省海洋水产研究所 | 2020-04-07 | — | — | CN | disclosed |
| US-20180338899-A1 | INHIBITORS FOR METHYLATION-RELATED ENZYMES HAT1 AND KAT8 | MIURA NORIMASA (JP) | 2018-11-29 | — | — | US | disclosed |
| EP-3369434-A1 | INHIBITORS FOR METHYLATION-RELATED ENZYMES HAT1 AND KAT8 | MIURA, Norimasa (JP) | 2018-09-05 | — | — | EP | disclosed |
| US-10004701-B2 | Methods and compositions for treating infection | UNIVERSITY OF ROCHESTER (US) | 2018-06-26 | — | — | US | disclosed |
| US-9861619-B2 | Antibiotic methods and compositions for bacteria infections | THE UNIVERSITY OF CHICAGO (US) | 2018-01-09 | — | — | US | disclosed |
| CN-107037140-A | A kind of method of cynnematin residual quantity in efficient detection aquatic products | 浙江省海洋水产研究所 | 2017-08-11 | — | — | CN | disclosed |
| US-20170065540-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | UNIVERSITY OF ROCHESTER (US) | 2017-03-09 | — | — | US | disclosed |
| US-9393221-B2 | Methods and compounds for reducing intracellular lipid storage | THE GENERAL HOSPITAL CORPORATION (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150283120-A1 | ANTIBIOTIC METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS | THE UNIVERSITY OF CHICAGO (US) | 2015-10-08 | — | — | US | disclosed |
| EP-2916653-A1 | ANTIBIOTIC METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS | The University of Chicago (US) | 2015-09-16 | — | — | EP | disclosed |
| US-20150238473-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-08-27 | — | — | US | disclosed |
| WO-2014071198-A1 | ANTIBIOTIC METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS | THE UNIVERSITY OF CHICAGO (US) | 2014-05-08 | — | — | WO | disclosed |
| US-20130023488-A1 | METHODS AND COMPOUNDS FOR REDUCING INTRACELLULAR LIPID STORAGE | THE GENERAL HOSPITAL CORPORATION (US) | 2013-01-24 | — | — | US | disclosed |
| US-20100305326-A1 | Chemical Fragment Screening and Assembly Utilizing Common Chemistry for NMR Probe Introduction and Fragment Linkage | MARQUETTE UNIVERSITY (US) | 2010-12-02 | — | — | US | disclosed |
| US-20100304998-A1 | Chemical Proteomic Assay for Optimizing Drug Binding to Target Proteins | MARQUETTE UNIVERSITY (US) | 2010-12-02 | — | — | US | disclosed |
| US-4678512-A | Marine coating compositions and method | GRAMS RALPH R | 1987-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150283120-A1 | ANTIBIOTIC METHODS AND COMPOSITIONS FOR BACTERIA INFECTIONS | OXA1L, VSIR, CUTA | HSD17B10 3231/4885THRB 2288/4885TSHR 3556/4885 |
| US-20150238473-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | MMP8, IFNG, MPO | HSD17B10 2515/4885THRB 4810/4885TSHR 4851/4885 |
| US-20100305326-A1 | Chemical Fragment Screening and Assembly Utilizing Common Chemistry for NMR Probe Introduction and Fragment Linkage | CYFIP2, RPS27A, FRS2 | HSD17B10 1893/4885THRB 3943/4885TSHR 4072/4885 |
| US-20170065540-A1 | METHODS AND COMPOSITIONS FOR TREATING INFECTION | MMP8, IFNG, MPO | HSD17B10 2515/4885THRB 4810/4885TSHR 4851/4885 |
| US-10004701-B2 | Methods and compositions for treating infection | MMP8, IFNG, MPO | HSD17B10 2515/4885THRB 4810/4885TSHR 4851/4885 |
| US-20220168384-A1 | Anti-Bacterial Combination Therapy | TST, SLC11A2, HAMP | HSD17B10 2947/4885THRB 926/4885TSHR 1853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.