Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefoperazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.99 |
| ▸ | THRB | P10828 | 1/20 | 0.99 |
| ▸ | TSHR | P16473 | 1/20 | 0.99 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.88 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 10/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefoperazone SCHEMBL16091123 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL37056 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL11522109 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL2222952 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL18061225 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL16072819 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL15387468 | 1.00 | MAPT (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL3758644 | 0.99 | HSD17B10 (1.00) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL40452 | 0.99 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A | |
| Cefoperazone SCHEMBL28649126 | 0.99 | MAPT (0.99) | MAPTSLC22A6SLC22A8SLC22A11PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | claimed |
| EP-0317484-B1 | N,N'-carboxyl-bis-(4-ethyl-2,3-dioxo)-piperazine, process for the preparation thereof and use thereof | GEMA SA (ES) | 1994-03-16 | — | — | EP | disclosed |
| US-5015736-A | Piperazine intermediates | GEMA, S.A. (ES) | 1991-05-14 | — | — | US | disclosed |
| US-4965358-A | N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine | GEMA, S. A. (ES) | 1990-10-23 | — | — | US | disclosed |
| EP-0317484-A2 | N,N'-carboxyl-bis-(4-ethyl-2,3-dioxo)-piperazine, process for the preparation thereof and use thereof | GEMA S.A. (ES) | 1989-05-24 | — | — | EP | disclosed |
| US-4656263-A | 6-β-substituted penicillanic acid compound free of the 6-α-epimer | PFIZER INC. (US) | 1987-04-07 | — | — | US | disclosed |
| US-4654331-A | Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group | MERCK & CO., INC. (US) | 1987-03-31 | — | — | US | disclosed |
| US-4518530-A | 6-β-Substituted penicillanic acids as β-lactamase inhibitors | PFIZER INC. (US) | 1985-05-21 | — | — | US | disclosed |
| US-4517126-A | Penicillanic acid derivative | PFIZER INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4479947-A | Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group | MERCK & CO., INC. (US) | 1984-10-30 | — | — | US | disclosed |
| US-4442090-A | ACYLATED AMINO ACID | KYOTO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1984-04-10 | — | — | US | disclosed |
| US-4432970-A | SYNERGISTIC WITH AMINO ACID DERIVATIVE ANTIBIOTICS | PFIZER INC. (US) | 1984-02-21 | — | — | US | disclosed |
| US-4397783-A | HYDRODEHALOGENATION WITH AN ORGANOTIN HYDRIDE | PFIZER INC. (US) | 1983-08-09 | — | — | US | disclosed |
| EP-0083977-A1 | 6-Alpha-hydroxymethylpenicillanic acid sulfone as a beta-lactamase inhibitor | PFIZER INC. (US) | 1983-07-20 | — | — | EP | disclosed |
| US-4316024-A | Dioxo piperazine compounds | BRISTOL-MYERS COMPANY (US) | 1982-02-16 | — | — | US | disclosed |
| US-4287181-A | TO ENHANCE THE EFFECTIVENESS OF B-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1981-09-01 | — | — | US | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |