Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519078 | 0.88 | GAA (0.55) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL519170 | 0.82 | ALDH1A1 (0.70) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24811169 | 0.80 | GAA (0.49) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL16273521 | 0.79 | GAA (0.48) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL3718869 | 0.78 | MAPK1 (0.42) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL765365 | 0.77 | MAPT (0.55) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL12998588 | 0.77 | MAPT (0.55) | NPC1RAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL7959649 | 0.77 | RAB9A (0.67) | GAANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL518930 | 0.77 | ALDH1A1 (0.56) | GAARAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL14973882 | 0.77 | MAPT (0.53) | GAANPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393360-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090737-A1 | PYRIDAZINONE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-12 | — | — | WO | disclosed |