Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32889381 | 0.83 | KEAP1 (0.50) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL12475636 | 0.83 | KEAP1 (0.50) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL2535316 | 0.80 | KEAP1 (0.51) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL3524315 | 0.80 | KEAP1 (0.47) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL296024 | 0.80 | KEAP1 (0.47) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL4424885 | 0.79 | NQO2 (0.57) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL19668867 | 0.77 | KEAP1 (0.45) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL296452 | 0.77 | KDR (0.53) | KEAP1NFE2L2ALDH1A1HPGDKDR | |
| SCHEMBL12822231 | 0.76 | MPO (0.44) | KEAP1NFE2L2ALDH1A1KDM4EGAA | |
| SCHEMBL12803649 | 0.76 | KEAP1 (0.44) | KEAP1NFE2L2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039858-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | OLEMA PHARMACEUTICALS, INC. (US) | 2024-02-22 | — | — | WO | disclosed |
| EP-3261638-B1 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS | NANTBIOSCIENCE INC (US) | 2019-05-08 | — | — | EP | disclosed |
| WO-2017098421-A1 | BENZOTHIADIAZINE COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-06-15 | — | — | WO | disclosed |
| EP-1474420-B1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2009030224-A2 | NOVEL QUINAZOLINE COMPOUNDS AND THE USE THEREOF FOR TREATING CANCEROUS DISEASES | SCHEBO BIOTECH AG (DE) | 2009-03-12 | — | — | WO | disclosed |
| EP-1309587-B1 | CINNOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | EP | disclosed |