Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3698404 | 0.89 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3699509 | 0.89 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3699832 | 0.89 | NAMPT (1.00) | NAMPT | |
| SCHEMBL6128294 | 0.84 | NAMPT (0.74) | NAMPT | |
| SCHEMBL3707922 | 0.84 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3701636 | 0.82 | NAMPT (1.00) | NAMPT | |
| SCHEMBL16565833 | 0.81 | ALDH1A1 (0.67) | NAMPT | |
| SCHEMBL3698325 | 0.80 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3710799 | 0.80 | NAMPT (1.00) | NAMPT | |
| SCHEMBL3703231 | 0.79 | NAMPT (1.00) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253562-A1 | Nampt Inhibitors | ABBVIE INC (US) | 2017-09-07 | — | — | US | claimed |
| US-9302989-B2 | NAMPT and rock inhibitors | ABBVIE INC. (US) | 2016-04-05 | — | — | US | claimed |
| US-20160031813-A1 | Nampt Inhibitors | ABBVIE INC. | 2016-02-04 | — | — | US | claimed |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| US-10093624-B2 | NAMPT and ROCK inhibitors | ABBVIE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-2776393-B1 | NAMPT INHIBITORS | ABBVIE INC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-20170253562-A1 | Nampt Inhibitors | ABBVIE INC (US) | 2017-09-07 | — | — | US | disclosed |
| US-9302989-B2 | NAMPT and rock inhibitors | ABBVIE INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-20160031813-A1 | Nampt Inhibitors | ABBVIE INC. | 2016-02-04 | — | — | US | disclosed |
| US-20160031880-A1 | Nampt and Rock Inhibitors | ABBVIE INC. (US) | 2016-02-04 | — | — | US | disclosed |
| EP-2776393-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2014-09-17 | — | — | EP | disclosed |
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2013067710-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10093624-B2 | NAMPT and ROCK inhibitors | NAMPT, NNMT, NADK | NAMPT 1/4885 |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | NAMPT, NNMT, NME2 | NAMPT 1/4885 |
| US-20170253562-A1 | Nampt Inhibitors | NAMPT, NNMT, NAPRT | NAMPT 1/4885 |
| US-20160031813-A1 | Nampt Inhibitors | NAMPT, NNMT, NAPRT | NAMPT 1/4885 |
| US-20160031880-A1 | Nampt and Rock Inhibitors | NAMPT, NNMT, NME2 | NAMPT 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.