Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL | Q9Y232 | 7/20 | 0.50 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 5/20 | 0.50 |
| ▸ | CBX7 | O95931 | 5/20 | 0.50 |
| ▸ | CDYL2 | Q8N8U2 | 5/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825258 | 0.69 | SMN1; SMN2 (0.63) | CDYLCDY1; CDY1BCBX7CDYL2PTPN1 | |
| SCHEMBL29236557 | 0.69 | GSK3B (0.63) | CDYLCDY1; CDY1BCBX7CDYL2PTPN1 | |
| SCHEMBL19673997 | 0.64 | CA12 (0.49) | ALDH1A1KDM4ECA12CA9MEN1 | |
| SCHEMBL29411099 | 0.63 | PTPN1 (1.00) | PTPN1GSK3BALDH1A1KDM4EHPGD | |
| SCHEMBL220588 | 0.63 | PTPN1 (1.00) | PTPN1GSK3BALDH1A1KDM4EHPGD | |
| SCHEMBL29489791 | 0.63 | PTPN1 (0.71) | PTPN1ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL1974978 | 0.63 | PTPN1 (0.71) | PTPN1ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL12532276 | 0.63 | PTPN1 (0.53) | CDYLCDY1; CDY1BCBX7CDYL2PTPN1 | |
| SCHEMBL203507 | 0.62 | PTPN1 (0.70) | CDYLCDY1; CDY1BCBX7CDYL2PTPN1 | |
| SCHEMBL2561428 | 0.62 | PTPN1 (0.65) | PTPN1ALDH1A1LMNAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710068-B2 | Method of treating cancer using a survivin inhibitor | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2014-04-29 | — | — | US | disclosed |
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010083505-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | BIRC5, CDC20, CCNB1 | CDYL 2304/4885CDY1; CDY1B 3538/4885CBX7 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.