Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.51 |
| ▸ | THRB | P10828 | 9/20 | 0.51 |
| ▸ | THRA | P10827 | 4/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706521 | 0.92 | RORC (0.53) | RORCTHRBTHRA | |
| SCHEMBL3709382 | 0.91 | RORC (0.51) | RORCTHRBTHRA | |
| SCHEMBL3712010 | 0.90 | NR3C1 (0.46) | RORCTHRBTHRANR3C1HTT | |
| SCHEMBL3706058 | 0.89 | RORC (0.51) | RORCTHRBTHRA | |
| SCHEMBL3233002 | 0.86 | RORC (0.55) | RORCTHRBTHRA | |
| SCHEMBL3711396 | 0.86 | RORC (0.49) | RORCTHRBTHRA | |
| SCHEMBL3711993 | 0.86 | THRB (0.45) | RORCTHRBTHRA | |
| SCHEMBL3709210 | 0.85 | THRB (0.41) | RORCTHRBTHRANR3C1 | |
| SCHEMBL3710472 | 0.85 | RORC (0.47) | RORCTHRBTHRA | |
| SCHEMBL3702743 | 0.85 | RORC (0.47) | RORCTHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |