Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.45 |
| ▸ | THRA | P10827 | 16/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806790 | 0.88 | MEN1 (0.45) | THRBTHRAMEN1KMT2A | |
| SCHEMBL3705094 | 0.85 | THRB (0.49) | THRBTHRAMEN1KMT2A | |
| SCHEMBL3711564 | 0.84 | THRA (0.56) | THRBTHRA | |
| SCHEMBL3703818 | 0.84 | THRB (0.47) | THRBTHRA | |
| SCHEMBL3708351 | 0.83 | THRA (0.47) | THRBTHRA | |
| SCHEMBL3706305 | 0.83 | THRB (0.53) | THRBTHRA | |
| SCHEMBL3706100 | 0.82 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3710196 | 0.82 | THRB (0.49) | THRBTHRA | |
| SCHEMBL3704858 | 0.82 | THRB (0.45) | THRBTHRA | |
| SCHEMBL3811467 | 0.82 | THRB (0.50) | THRBTHRAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086878-A2 | THYROID RECEPTOR MODULATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-08-05 | — | — | WO | disclosed |