SCHEMBL3710196

SCHEMBL3710196

O=C(O)CN(C(=O)c1cccc(O)c1)c1cc(Br)c(Oc2ccc(O)c(-c3ccccc3)c2)c(Br)c1

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRB P10828 19/20 0.49
THRA P10827 18/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3703818 0.90 THRB (0.47) THRBTHRA
SCHEMBL3706100 0.87 THRB (0.45) THRBTHRA
SCHEMBL3788364 0.85 THRB (0.44) THRBTHRA
SCHEMBL3811467 0.84 THRB (0.50) THRBTHRA
SCHEMBL3703977 0.84 THRA (0.57) THRBTHRA
SCHEMBL3706305 0.83 THRB (0.53) THRBTHRA
SCHEMBL3704858 0.83 THRB (0.45) THRBTHRA
SCHEMBL3706583 0.82 THRB (0.45) THRBTHRA
SCHEMBL3712021 0.82 THRB (0.42) THRBTHRA
SCHEMBL3708478 0.82 THRB (0.42) THRBTHRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010086878-A2 THYROID RECEPTOR MODULATORS CADILA HEALTHCARE LIMITED (IN) 2010-08-05 WO disclosed