Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.45 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.40 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.39 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707275 | 0.94 | LPAR1 (0.40) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3710136 | 0.92 | LPAR1 (0.42) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL1247060 | 0.87 | SCN9A (0.51) | MAPTKDM4ESCN9ASCN5AALDH1A1 | |
| SCHEMBL3706624 | 0.86 | SCN9A (0.38) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL3712506 | 0.85 | LPAR1 (0.46) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL1246383 | 0.83 | SCN9A (0.51) | MAPTKDM4ESCN9ASCN5AALDH1A1 | |
| SCHEMBL12468286 | 0.82 | MAPT (0.48) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL13283821 | 0.82 | LPAR1 (0.66) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL2335320 | 0.82 | LPAR1 (0.53) | LPAR1LPAR3LPAR2MAPTKDM4E | |
| SCHEMBL2332531 | 0.81 | LPAR1 (0.52) | LPAR1LPAR3LPAR2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |