Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MTTP | P55157 | 2/20 | 0.32 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.32 |
| ▸ | CTSV | O60911 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743679 | 1.00 | GPR139 (0.35) | GPR139NR3C1PDE2AFFAR1CTSA | |
| SCHEMBL2548040 | 1.00 | GPR139 (0.35) | GPR139NR3C1PDE2AFFAR1CTSA | |
| SCHEMBL12241693 | 0.90 | CTSK (0.37) | GPR139NR3C1PDE2AFFAR1KMT2A | |
| SCHEMBL1744300 | 0.84 | CTSA (0.38) | GPR139PDE2AFFAR1CTSANPC1 | |
| SCHEMBL2548361 | 0.83 | FFAR2 (0.33) | PDE2AFFAR1CTSAKMT2APTGER4 | |
| SCHEMBL2548358 | 0.83 | FFAR2 (0.33) | PDE2AFFAR1CTSAKMT2APTGER4 | |
| SCHEMBL2551183 | 0.83 | FFAR1 (0.33) | GPR139NR3C1PDE2AFFAR1CTSA | |
| SCHEMBL1595429 | 0.82 | PDE2A (0.39) | PDE2A | |
| SCHEMBL1595431 | 0.82 | PDE2A (0.39) | PDE2A | |
| SCHEMBL1744761 | 0.81 | CNR2 (0.34) | PDE2AFFAR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |