Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18979088 | 0.87 | ALDH1A1 (0.48) | MAPTMAPK1MEN1KMT2AL3MBTL1 | |
| SCHEMBL29618075 | 0.87 | ALDH1A1 (0.48) | MAPTMAPK1MEN1KMT2AL3MBTL1 | |
| SCHEMBL6561044 | 0.81 | MAPT (0.58) | MAPTMAPK1MEN1KMT2AHPGD | |
| SCHEMBL15544886 | 0.80 | MAPT (0.44) | MAPTMAPK1L3MBTL1HPGDUCHL3 | |
| SCHEMBL3708261 | 0.79 | KMT2A (0.37) | MAPTMAPK1MEN1KMT2AHPGD | |
| SCHEMBL3645280 | 0.77 | ALDH1A1 (0.38) | MAPTMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL19002845 | 0.77 | CRHBP (0.38) | MAPTMAPK1MEN1KMT2AL3MBTL1 | |
| SCHEMBL25360169 | 0.76 | ALDH1A1 (0.43) | MAPTMAPK1MEN1KMT2AHPGD | |
| SCHEMBL26098394 | 0.75 | ALDH1A1 (0.37) | MAPTMAPK1MEN1KMT2AL3MBTL1 | |
| SCHEMBL20918708 | 0.75 | KDM4E (0.45) | MAPTMAPK1L3MBTL1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391623-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088177-A1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2010-08-05 | — | — | WO | disclosed |