Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL908706 | 0.78 | MERTK (0.37) | CRHBPCRHR2MERTKMAPTMAPK1 | |
| SCHEMBL16693759 | 0.78 | APOBEC3A (0.38) | MAPTMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14088962 | 0.78 | POLB (0.47) | MAPTMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18979088 | 0.77 | ALDH1A1 (0.48) | MAPTMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3707609 | 0.77 | MAPT (0.47) | MERTKMAPTMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29618075 | 0.77 | ALDH1A1 (0.48) | MAPTMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL27046184 | 0.76 | APP (0.34) | MAPTMAPK1ALDH1A1APP | |
| SCHEMBL2116753 | 0.75 | ALDH1A1 (0.41) | CRHBPCRHR2MERTKMAPTALDH1A1 | |
| SCHEMBL30503540 | 0.74 | CRHBP (0.59) | CRHBPCRHR2MERTKMAPTALDH1A1 | |
| SCHEMBL15718645 | 0.74 | SIRT2 (0.36) | CRHBPCRHR2ALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3181560-A1 | PYRIDINE AMIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | Shanghai Allist Pharmaceuticals, Inc. (CN) | 2017-06-21 | — | — | EP | disclosed |