Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3394496 | 0.99 | PIM1 (0.38) | PIM1PIM2PRMT6HDAC6TYMS | |
| SCHEMBL3713576 | 0.85 | SLC2A1 (0.42) | PIM1PIM2PRMT6TYMSGRM2 | |
| Hydrochloric Acid SCHEMBL3398480 | 0.84 | SLC2A1 (0.41) | PIM1PIM2PRMT6TYMSGRM2 | |
| SCHEMBL3712620 | 0.84 | SLC2A1 (0.41) | PIM1PIM2PRMT6TYMSGRM2 | |
| Hydrochloric Acid SCHEMBL3394437 | 0.84 | SLC2A1 (0.40) | PIM1PIM2PRMT6TYMSGRM2 | |
| SCHEMBL3705658 | 0.83 | SLC2A1 (0.35) | PIM1PIM2PRMT6HDAC6GRM2 | |
| Hydrochloric Acid SCHEMBL3397627 | 0.83 | SLC2A1 (0.34) | PIM1PIM2PRMT6HDAC6GRM2 | |
| SCHEMBL3705545 | 0.82 | PRMT6 (0.37) | PIM1PIM2PRMT6PTGDR2ACHE | |
| Hydrochloric Acid SCHEMBL3394460 | 0.81 | ACHE (0.37) | PRMT6PTGDR2PRMT1ACHE | |
| SCHEMBL3707693 | 0.80 | PRMT6 (0.40) | PIM1PIM2PRMT6SLC2A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |