Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2406614 | 0.86 | HTT (0.47) | S1PR1S1PR3SLC6A4LMNAKMT2A | |
| SCHEMBL9026143 | 0.84 | S1PR1 (0.56) | S1PR1S1PR3CALM1LMNAKMT2A | |
| SCHEMBL8715027 | 0.82 | TAAR1 (0.47) | LMNAALDH1A1TSHRKDM4EALOX5 | |
| SCHEMBL31236986 | 0.82 | TAAR1 (0.47) | LMNAALDH1A1TSHRKDM4EALOX5 | |
| SCHEMBL6809980 | 0.81 | ALDH1A1 (0.55) | CALM1LMNAKMT2AALDH1A1TSHR | |
| SCHEMBL28620316 | 0.80 | LMNA (0.41) | CALM1SLC6A4LMNAKMT2ANPSR1 | |
| SCHEMBL5873476 | 0.79 | CALM1 (0.67) | S1PR1S1PR3CALM1TSHRKDM4E | |
| SCHEMBL2408767 | 0.79 | LMNA (0.41) | CALM1SLC6A4LMNAKMT2ANPSR1 | |
| SCHEMBL11022505 | 0.77 | KDM4E (0.55) | S1PR1S1PR3CALM1LMNAKMT2A | |
| SCHEMBL12132523 | 0.77 | S1PR1 (0.47) | S1PR1S1PR3CALM1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212317-A1 | 4,4-DISUBSTITUTED PIPERIDINES | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009053452-A1 | 4,4-DISUBSTITUTED PIPERIDINES | NOVARTIS AG (CH) | 2009-04-30 | — | — | WO | disclosed |