Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 3/20 | 0.35 |
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | RXRB | P28702 | 5/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364586 | 0.80 | GPBAR1 (0.34) | GPBAR1RXRARXRBEPHX2LMNA | |
| SCHEMBL364577 | 0.73 | CYP19A1 (0.32) | — | |
| SCHEMBL362336 | 0.72 | KIF11 (0.32) | — | |
| SCHEMBL362349 | 0.71 | TTR (0.31) | ALOX5 | |
| SCHEMBL364014 | 0.70 | — | — | |
| SCHEMBL362881 | 0.69 | CHRM3 (0.37) | EDNRBEDNRA | |
| SCHEMBL8119878 | 0.66 | RXRA (0.66) | RXRARXRBRXRGPOLB | |
| SCHEMBL370900 | 0.62 | GPBAR1 (0.80) | GPBAR1NR1H4VCPRXRARXRB | |
| SCHEMBL1390281 | 0.62 | GPBAR1 (0.80) | GPBAR1NR1H4VCPRXRARXRB | |
| SCHEMBL364364 | 0.61 | GPBAR1 (0.63) | GPBAR1NR1H4VCPRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |