Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715125 | 0.90 | CCNC (0.42) | CCNCCDK8CDK19BDKRB1CAMKK2 | |
| SCHEMBL3718099 | 0.90 | MMP2 (0.44) | PIK3CDMMP2MMP8MMP13 | |
| SCHEMBL3713020 | 0.90 | PIK3CD (0.41) | CCNCCDK8CDK19PIK3CDCAMKK2 | |
| SCHEMBL3721418 | 0.89 | CCNC (0.41) | CCNCCDK8CDK19BDKRB1CAMKK2 | |
| SCHEMBL13187977 | 0.84 | CCNC (0.45) | CCNCCDK8CDK19BDKRB1CAMKK2 | |
| SCHEMBL3713512 | 0.83 | TBK1 (0.43) | MAPK1SMN1; SMN2TBK1MMP2MMP8 | |
| SCHEMBL3713224 | 0.83 | JAK2 (0.41) | PIK3CDCAMKK2MMP2MMP8MMP13 | |
| SCHEMBL3714355 | 0.81 | MMP2 (0.42) | CCNCCDK8CDK19MMP2MMP8 | |
| SCHEMBL3710999 | 0.81 | CCNC (0.41) | CCNCCDK8CDK19CAMKK2MMP2 | |
| SCHEMBL3721229 | 0.80 | SLC2A1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |