Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845914 | 0.88 | THRA (0.46) | THRATHRBHDAC1HDAC6NPC1 | |
| SCHEMBL1847562 | 0.82 | KMT2A (0.46) | THRATHRBHDAC1HDAC6NPC1 | |
| SCHEMBL1845523 | 0.77 | HDAC1 (0.39) | HDAC1HDAC6KMT2ATDP1PLAAT3 | |
| SCHEMBL1845524 | 0.77 | HDAC1 (0.39) | HDAC1HDAC6KMT2ATDP1PLAAT3 | |
| SCHEMBL658810 | 0.76 | PDPK1 (0.64) | HDAC1NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL960035 | 0.74 | SMN1; SMN2 (0.45) | NPC1RAB9AKMT2AHSD11B1HPGD | |
| SCHEMBL3645623 | 0.72 | KMT2A (0.43) | HDAC1NPC1RAB9AKMT2ACASP3 | |
| SCHEMBL991611 | 0.72 | KMT2A (0.43) | HDAC1NPC1RAB9AKMT2AHSD11B1 | |
| SCHEMBL2018753 | 0.72 | TAAR1 (0.55) | HDAC1HDAC6KMT2ATDP1HPGD | |
| SCHEMBL16507094 | 0.72 | LPAR1 (0.60) | HDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393807-A1 | CYCLIC INHIBITORS OF 11 -HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010089303-A1 | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-08-12 | — | — | WO | disclosed |